BDBM66087 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridinone::2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-pyridone::2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one::2-azanylethanol;6-cyclohexyl-4-methyl-1-oxidanyl-pyridin-2-one::Ciclopirox::Ciclopirox ethanolamine::MLS002153867::SMR001233223::cid_38911

SMILES Cc1cc(C2CCCCC2)n(O)c(=O)c1

InChI Key InChIKey=SCKYRAXSEDYPSA-UHFFFAOYSA-N

Data  1 KI  8 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 66087   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College Of Medicine

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataKi: >5.00E+4nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Weill Medical College of Cornell University

LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50:  4.50E+3nMAssay Description:The predication of no specific interaction between enzyme and iron-binding inhibitors but the Enzyme inhibition constants (IC50s)will change in paral...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug and toxin extrusion protein 1(Homo sapiens (Human))
University Of California

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4B(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of GST-tagged KDM4B (unknown origin) using H3K9(me3)-biotin peptide as substrate incubated for 30 mins and measured after 15 mins by TR-FR...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetATP-binding cassette sub-family C member 4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyhypusine hydroxylase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of DOHH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVacuolar aminopeptidase 1(Saccharomyces cerevisiae)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataEC50:  5.34E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetATP-binding cassette sub-family C member 3(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM66087(2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methyl-2-p...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed